Postulating the subcortical organization of human consciousness provides a critical link for the construal of pain in patients with impaired cortical function or cortical immaturity during early development. Practical implications of the centrencephalic proposal include the redefinition of pain, improved pain assessment in nonverbal humans, and benefits of adequate analgesia/anesthesia for these patients, which certainly justify the rigorous scientific efforts required. (Published Online May 1 2007).

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

The aim of this report is to present an example of a multidisciplinary Indian-Swedish co-operation on ethics in health care. It is based on a conference held in Asia Plateau, Panchgani, Maharasthra, India in 1998. The emphasis is on ethical values that are important for consumers of health care and professionals, and also for different cultures in developed and developing countries. The importance of human dignity is stressed. Sixteen recommendations are given in an appendix.

Is the existence of God a question of fact? To the majority of theists, both now and in the past, I think it has seemed clear that, if the phrase ‘God exists’ is to be meaningful, then it is a fact, either that God exists or that he does not. This assertion may even seem trivially true; and yet it has evidently been denied, in recent years, by many theologians. The reasons for such a denial are, in part, to be (...) found in the general reaction against metaphysical philosophy, which was characteristic of the early years of this century, and which is, in Britain, epitomised by A. J. Ayer's stipulation that no proposition can be factually significant unless it is verifiable; unless, in principle at least, some series of observations could conceivably show it to be true. By restricting ‘observation’ to the senses of the physical body, and by emphasising the fact that God, as transcendent by definition, was not a possible object of the senses, some philosophically sensitive theologians were startled into denying that ‘God’ was, even in principle, verifiable; and consequently into denying that propositions purporting to assert his existence were factual. (shrink)

In this paper we distinguish two competing conceptions of dignity, one recognizably Hobbesian and one recognizably Kantian. We provide a formal model of how decision-makers committed to these conceptions of dignity might reason when engaged in an economic transaction that is not inherently insulting, but in which it is possible for the dignity of the agent to be called into question. This is a modified version of the ultimatum game. We then use this model to illustrate ways in which the (...) Kantian evaluative standpoint enjoys a kind of internal stability that the Hobbesian framework lacks. Our interpersonal argument shows that, under certain conditions, Hobbesians prefer to cultivate Kantian commitments in others and promote the presence of Kantians in the population. Our intrapersonal argument shows that agents who are conflicted between Kantian and Hobbesian commitments have powerful reasons not to resolve this commitment in favour of Hobbesian values. Our emulation argument illustrates that in repeated versions of the ultimatum game, the Hobbesian chooses to behave like a Kantian, including publicly repudiating her Hobbesian commitments. Here again, however, the Hobbesian is able to achieve a desired benefit only on the condition that there are genuine Kantians in the population. Finally, our social planning argument explores the reasons why a community of Hobbesians would opt to enshrine a Kantian conception of dignity into law. The paper concludes with some remarks about the policy implications of this work. The value or worth of a man is, as for all other things, his price, that is to say, so much as would be given for the use of his power; and therefore is not absolute, but a thing dependent on the need and judgement of another... The public worth of a man, which is the value set on him by the Common-wealth, is that which men commonly call DIGNITY. Hobbes, _Leviathan X_, 16. (shrink)

This paper reports a study of planning processes in the five-disc Tower of London (TOL) task in 20 younger and 20 older adult participants. A concurrent direct ''think-aloud'' method was used to obtain data on planning processes prior to moving discs in the TOL. A check was made of the effects of verbalising by comparing performance data from the experimental groups with data from control groups who did not verbalise during planning or moving. Verbalising slowed down planning and moving but (...) did not appear to distort the participants' approaches to the task. Older and younger participants did not differ in average moves taken to solve the tasks. However, older participants' planning was less complete and more error-prone than that of younger participants. The planning processes were characterised as showing a means-ends ''goal selection'' strategy. In this strategy participants (1) identify a single active goal disc at the start, (2) select moves and move sequences to enable the placing of the current goal disc in its target position, and (3) continue in this way until all discs are in their target positions. Age differences were found in the planning stage, during which there was no stimulus support and hence a substantial working memory load. During the move phase there was stimulus support and hence little loading of working memory. Age differences in moves required were not found in the move phase. As older participants tend to have depleted working memory capacity the present results suggest that working memory is heavily loaded in TOL planning but less so in the move phase of TOL. (shrink)

This paper reports a study of the roles of visuo-spatial and verbal working memory capacities in solving a planning task - the five-disc Tower of London (TOL) task. An individual differences approach was taken. Sixty adult participants were tested on 20 TOL tasks of varying difficulty. Total moves over the 20 TOL tasks was taken as a measure of performance. Participants were also assessed on measures of fluid intelligence (Raven's matrices), verbal short-term storage (Digit span), verbal working memory span (Silly (...) Sentence span), visuo-spatial short-term storage (Visual Pattern span and Corsi Block span), visuo-spatial working memory (Corsi Distance Estimation), visuo-spatial processing speed (Manikin test), and verbal speed (Rehearsal speed). Exploratory factor analysis using an oblique rotation method revealed three factors which were interpreted as (1) a visuo-spatial working memory factor, (2) an age-speed factor, and (3) a verbal working memory factor. The visuo-spatial and verbal factors were only moderately correlated. Performance on the TOL task loaded on the visuo-spatial factor but did not load on the other factors. It is concluded that the predominant goal-selection strategy adopted in solving the TOL relies on visuo-spatial working memory capacity and particularly involves the active ''inner scribe'' spatial rehearsal mechanism. These correlational analyses confirm and extend results previously obtained by use of dual task methods, (Phillips, Wynn, Gilhooly, Della Sala, & Logie, 1999). (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Considering CertificationAnand Jayprakash Vaidya (bio)Jewel of Reflection on the Truth about Epistemology: A Complete and Annotated Translation of the Tattva-cintā-maṇi. Volume 1, Perception. Volume 2, Inference. Translated by Stephen Phillips. London: Bloomsbury.I. IntroductionStephen Phillips' Jewel of Reflection on the Truth about Epistemology is a masterful translation and commentary on the books originally written by Gaṅgeśa, the fourteenth-century father of the Navya-Nyāya tradition of Indian philosophy. Jewel is one of (...) the most highly regarded works in Indian epistemology, one that rivals the work of Immanuel Kant in terms of its depth and significance. While J. N. Mohanty (1966) and B. K. Matilal (1968) translated portions of Gaṅgeśa's Jewel, only Phillips (2020) offers a complete translation—one that will serve as the foundation for any future study of Gaṅgeśa. In what follows, I will not be focusing on issues of translation or interpretation pertaining to the text. Rather, I will be engaging Phillips' account of Gaṅgeśa (hereafter Phillips) with the aim of bringing Gaṅgeśa's Jewel into contact with a debate in contemporary epistemology. I believe Gaṅgeśa's distinction between perceptual knowledge and certification has a lot to offer contemporary epistemology.The point of departure for my engagement with Phillips is the debate over internalism and externalism about knowledge.1 One account of the debate is that there is a disagreement over whether the KK principle is true. The KK principle states that when x knows that p, x knows that x knows that p. Internalists hold that knowledge is a wholly internal affair, and thus they accept the KK principle. More specifically, awareness internalists hold that x knows that p only when x is also aware of x's knowledge basis for p. By contrast, access internalists hold a weaker claim: x knows that p only when x can become aware, by reflection, of x's knowledge basis for p. Externalists typically deny some version of the KK principle. On one version of externalism, knowledge is justified true belief + some anti luck condition, and to have a justified true belief is for the belief to be formed on the basis of a reliable belief-forming process whether or not the subject knows anything about the workings of the belief-forming process. Externalists hold [End Page 486] that x can know that p, without having any reflective access to the knowledge basis for p.2 However, some analytic philosophers object to the internalismexternalism debate. In a now classic set of essays, Tyler Burge (1993, 2003) moves around the internalism-externalism debate by drawing a distinction between two types of warrant: entitlement and justification—where entitlement plays an externalist role, and justification plays an internalist role.The internalism-externalism distinction does not exist in Indian epistemology. In Indian epistemology, there is a distinction between intrinsic and extrinsic validity. This distinction only superficially resembles the internalism-externalism contrast found in the analytic tradition.3 Just as Indian epistemologists did not draw the distinction between a priori and a posteriori knowledge, they also did not draw the distinction between justification being a wholly internal affair versus justification being a wholly external affair.Can the absence of the internalism-externalism debate in classical Indian epistemology be used to draw an alternative map of epistemic relations, one that competes with Burge's distinction between entitlement and justification? Stephen Phillips' (2012) work on Nyāya epistemology in combination with his translation and commentary on Jewel allows for an opportunity to explore this question. In section II, I present Burge's account of the dual warrants of entitlement and justification. In section III, I present Phillips' account of perceptual knowledge and certified knowledge. In section IV, I use both theories to analyze a case of perceptual knowledge. In section V, I turn to a comparative analysis of Burge's and Phillips' views, to open up the issue for further debate and discussion.II. Tyler Burge on Entitlement and JustificationIn his 1993 and 2003 articles Burge offers an alternative way of seeing the internalism-externalism debate about justification. In his 1993 work he distinguishes between justification... (shrink)

Perceptual disjunctivism is a controversial thesis about perception. One familiar characterization of the thesis maintains that there is no common epistemic kind that is present in both veridical and non-veridical cases of perception. For example, the good case, in which one sees a yellow lemon, and the bad case, in which one hallucinates a yellow lemon, share a specific first-person phenomenology, being indistinguishable from the first-person point of view; however, seeing a yellow lemon and hallucinating a yellow lemon do not, (...) according to the disjunctivist, share a common epistemic kind. There are two types of disjunctivism: epistemological vs. metaphysical. John McDowell, 243–255, 2011, Philosophical Explorations, 16, 259–279, 2013) has articulated, refined, and defended one kind of disjunctivism. Tyler Burge, 1–78, 2005, Philosophical Explorations, 13, 43–80, 2011) has objected to many forms of disjunctivism, arguing that they are all inconsistent with the proximality principle in the vision sciences. PP requires an ability-general kind in common between relevantly similar perceptual states, such as seeing a yellow lemon and hallucinating a yellow lemon, which disjunctivism denies. Against the background of this debate some analytic epistemologists, such as Michael Martin, Alan Millar, 176–198, 2007), Berit Brogaard, 46–73, 2011), Duncan Pritchard, and Heather Logue, 105–133, 2013) remain attracted to some version of disjunctivism. Brogaard and Pritchard each have gone on to articulate and defend a version. Pritchard’s, for example, defends epistemological disjunctivism. Martin, Millar, and Logue, by contrast, have defended the idea that the disjunctivist is right about something, but perhaps not wholly correct about the nature of perception. In what follows, I articulate and defend the view that an interesting kind of disjunctivism is to be found through a reading of the Nyāya School of classical Indian philosophy. I articulate a version of perceptual disjunctivism informed by Nyāya perceptual theory that is not derivable from any single Nyāya philosopher. The view I offer is inspired by work on disjunctivism both in Anglo-analytic philosophy and in Nyāya scholarship, such as by Dasti and Phillips, 535–540, 2010), Ganeri, 541–550, 2010), Dasti, 1–15, 2012), Phillips, Vaidya, 562–585, 2013), and Schiller, 1–18, 2019). Importantly, the causal account I offer is distinct from Grice’s single-factor causal theory of perception by crucially involving a multi-factor causal theory of perception. My work on Nyāya perceptual theory derives primarily from Jaysankar Shaw’s account of Nyāya on the sources of knowledge, which is distinct from Stephen Phillips’ well-known account of Nyāya epistemology. Shaw’s theory has been developed and refined through textual analysis and dialectical engagement with the twentieth century Nyāya Pundit Philosopher, Viśvabandhu Tarkatīrtha. Like other modern Nyāya scholars, such as B. K. Matilal, A. Chakrabarti, 1–8, 2010), M. Chadha, J. Ganeri, and S. Phillips, 104–113, 2001, 2012), J. Shaw’s account shows how Nyāya epistemology is a living and continuing form of Indian philosophy. My goal here is twofold. On the one hand, I articulate multi-factor causal disjunctivism and show how it can be applied to the McDowell-Burge debate over the viability of disjunctivism and naïve realism. On the other hand, I aim to start a cross-cultural epistemological conversation with those that have contributed to the Anglo-analytic debate in anthologies, such as Haddock and Macpherson, Byrne and Logue, and introductions, such as Soteriou. The hope is that a cross-cultural epistemological investigation into disjunctivism will lead to better epistemic theorizing about the nature of perception. (shrink)

Fourth-year medical students at the University of Colorado School of Medicine distributed cards to patients in the emergency department asking, "What Worries You Most?" The patients' responses provided insight about their most pressing concerns, often unrelated to their "chief complaints.".

In this article the perspective shifts to the “upstream” end of the agricultural knowledge and information system (AKIS). Because knowledge policy and strategic decision-making are not the prerogative of the public sector, organizations such as cooperative unions and multinational companies are included. After considering the influence of the changing environment on the nature of the AKIS, the role of knowledge management and policy in the emerging knowledge and information market is examined. Special attention is given to public and private R&D. (...) The article then looks where information technology (IT) fits in and what considerations determine strategic investment in IT projects and sustained services. Some of the European experiences with this strategic investment are evaluated. (shrink)

As part of a larger research study, we present model language for disclosing financial interests in clinical research to potential research participants, and we describe the empirical basis and theoretical assumptions used in developing the language. The empirical process for creating appropriate disclosure language resulted in a generic disclosure statement for cases in which no risk to participants’ welfare or the scientific integrity of the research is expected, and nine more specific disclosure statements for cases in which some risk is (...) expected. The disclosure statements are not meant to be canonical, but were instead designed to reflect the typical situations in which disclosure of financial interest might be considered by an institutional review board or conflict of interest committee. Individual institutions could modify key phrases to suit their purposes, and others could use the language in future empirical work on informed consent to better refine the options for disclosing financial interests in clinical research. (shrink)

The integrated information theory is a promising theory of consciousness. However, there are several problems with IIT's axioms and postulates. Moreover, IIT entails that some twodimensional grids of identical logic gates have more consciousness than humans. Many have found this prediction to be implausible, and as will be argued here, this prediction also exacerbates the so-called 'hard problem of consciousness'. Recently, it has been argued that if we treat the phenomenological aspects of consciousness as an illusion, we can avoid the (...) hard problem altogether by replacing it with the more tractable illusion problem: the problem of explaining how introspection systematically misrepresents experiences as having phenomenology. IIT is intended to be a theory of the phenomenological aspects of consciousness. However, it is possible to reformulate the axioms and postulates of IIT consistently with illusionism. Here it is argued that the resulting theory -- illusionist integrated information theory -- removes several problems for IIT including the hard problem and the logic gate problem, and also enables meaningful progress for illusionists on solving the illusion problem. (shrink)

Two firm points in the chronology of Antiphon's speeches are VI περ το χορευτο in 419/81 and the Defence in 411/02. Speech V περ τσ 'Hρδου is now generally dated between these two; only the vaguest attempts have been made to date I κατ τσ μητρυασ; there is no general agreement on either the date or the authorship of the Tetralogies. The main purpose of this paper is to adduce linguistic as well as external evidence for the dating of V (...) in the neighbourhood of 414 and to show grounds for dating I between VI and V. Its secondary purpose is to apply some of the results gained in this inquiry to the fragments and the Tetralogies. (shrink)